Spicy Southwest Chicken Alfredo Recipe That Wows Every Time

Creamy pasta dishes hold a special charm that captures hearts across dinner tables.

This mouthwatering southwest chicken alfredo recipe brings a zesty twist to the classic comfort food.

Spicy southwestern spices dance beautifully with smooth, rich alfredo sauce, creating a flavor explosion that will surprise your palate.

Tender chicken pieces nestle perfectly among pasta strands, delivering a bold and satisfying meal.

Packed with vibrant ingredients and easy to prepare, this recipe promises a delightful dining experience.

Fresh herbs and a sprinkle of bold seasonings elevate this dish from ordinary to extraordinary.

You’ll want to savor every single bite of this southwestern-inspired culinary delight.

Why You’ll Love Southwest Chicken Alfredo

• Dive into a recipe that transforms ordinary chicken into a flavor-packed adventure with its vibrant blend of chili powder, cumin, and cayenne.
• Craft a restaurant-quality meal right in your kitchen with minimal effort, using just one skillet and straightforward ingredients that come together effortlessly.
• Blend creamy Alfredo sauce with zesty southwest seasonings to create a dish that satisfies both pasta lovers and spice enthusiasts, making it perfect for family dinners or casual gatherings.
• Easily adapt the recipe by adjusting spice levels, swapping proteins, or adding extra vegetables to make it uniquely yours while maintaining its delicious core flavors.

What You Need for Southwest Chicken Alfredo

• Chicken Strips: Tender meat that serves as the primary protein and flavor carrier for the Southwest-style dish.

• Chili Powder, Cumin, Oregano, Paprika, Black Pepper, Salt, Cayenne: A robust seasoning mix that provides a complex and vibrant Southwest flavor profile to the chicken and sauce.

• Penne Pasta: Classic pasta shape that holds the creamy sauce well and provides a hearty foundation for the dish.

• Heavy Cream: Creamy base that creates a rich and smooth sauce texture.
• Cheddar Cheese: Sharp cheese that melts into the sauce, adding depth and creaminess.

• Onions, Garlic: Foundational ingredients that build a flavor base for the sauce.
• Diced Tomatoes: Adds moisture, acidity, and a slight tangy element to the dish.

• Honey: Provides a subtle sweetness that balances the spicy seasoning.
• Cilantro: Fresh herb that adds brightness and a classic Southwest garnish.

• Olive Oil, Butter: Help with sautéing and contribute to the overall richness of the dish.

Cooking Southwest Chicken Alfredo

Step 1: Craft Spicy Southwest Seasoning

Blend together a zesty mix in a small bowl with chili powder, cumin, oregano, paprika, black pepper, salt, and cayenne.

This explosive seasoning will transform your chicken into a flavor powerhouse.

Step 2: Marinate Chicken Strips

Toss chicken strips in a large bowl with honey and generously coat them with half of the southwest seasoning.

Ensure each strip is thoroughly covered for maximum taste sensation.

Step 3: Boil Perfect Pasta

Fill a large pot with water and bring to a rolling boil.

Cook penne pasta until it reaches al dente perfection.

Drain and set aside, ready to absorb the upcoming creamy goodness.

Step 4: Sear Golden Chicken

Heat olive oil in a large skillet over medium heat.

Place seasoned chicken strips and cook until each side turns a beautiful golden brown.

Transfer cooked chicken to a plate.

Step 5: Caramelize Onions

In the same skillet, melt butter and add chopped onions.

Saute until they become soft, translucent, and develop a sweet, rich flavor.

Step 6: Build Flavor Base

Add minced garlic and cook until aromatic.

Introduce diced tomatoes and remaining seasoning mix.

Simmer gently to marry all the spicy elements.

Step 7: Create Creamy Sauce

Slowly pour heavy cream into the skillet, stirring continuously.

Maintain a gentle simmer to thicken the sauce and blend the robust flavors.

Step 8: Reunite Chicken and Cheese

Return chicken strips to the skillet.

Sprinkle shredded cheddar cheese over the top and stir until the cheese melts completely, creating a luxurious coating.

Step 9: Marry Pasta with Sauce

Add cooked penne to the skillet.

Toss thoroughly to ensure every pasta piece is generously covered with the creamy, spicy sauce.

Step 10: Let Flavors Harmonize

Remove skillet from heat and allow the dish to rest for a few minutes.

This brief pause helps the flavors meld and intensify.

Step 11: Garnish and Serve

Give the pasta a final stir.

Sprinkle fresh chopped cilantro on top for a bright, herbal finish.

Serve hot and enjoy your Southwest Chicken Alfredo adventure!

Tips to Enhance Chicken Alfredo

• Adjust cayenne pepper amount to match your heat tolerance, ensuring the dish is perfectly seasoned without overwhelming spiciness.
• Rinse pasta with cold water after cooking to stop the cooking process and prevent overcooking, maintaining ideal al dente texture.
• Grate cheese at room temperature for smoother melting and more even distribution throughout the creamy sauce.
• Swap penne pasta with zucchini noodles or cauliflower rice for a lighter, low-carbohydrate version of this southwestern dish.
• Substitute chicken with shrimp or plant-based protein like tofu for diverse dietary preferences while maintaining the recipe's robust flavor profile.

Storing Southwest Chicken Alfredo Correctly

• Transfer leftover Southwest Chicken Alfredo to an airtight container within 2 hours of cooking. Seal tightly and store in the refrigerator for up to 3-4 days to maintain optimal flavor and food safety.
• Portion the pasta into freezer-safe containers or heavy-duty freezer bags. Remove as much air as possible to prevent freezer burn. Freeze for up to 2 months, keeping the dish's texture and taste intact.
• Place a single serving in a microwave-safe dish. Add a splash of cream or milk to restore moisture. Cover and heat in 30-second intervals, stirring between each interval until the pasta is heated through and sauce is creamy.
• Pour the leftovers into a skillet over medium-low heat. Add a little cream or chicken broth to prevent drying. Stir gently and consistently until the pasta is thoroughly warmed and sauce regains its creamy consistency.

What to Eat with Southwest Chicken Alfredo

• Pair Zesty Southwest Chicken with Crisp White Wine: A bright, citrusy Sauvignon Blanc cuts through the rich, creamy sauce and complements the spicy southwestern seasonings perfectly.
• Refresh with Mexican-Style Lager: A cold, light Mexican beer like Corona or Modelo Especial balances the dish's heat and provides a crisp, clean accompaniment that enhances the meal's bold flavors.
• Cool Down with Creamy Avocado Salad: Create a simple side salad with fresh avocado, lime juice, and cilantro to provide a cool, creamy contrast to the spicy, warm chicken alfredo.
• Brighten with Cucumber Lime Mocktail: Mix fresh cucumber, lime juice, and sparkling water for a refreshing non-alcoholic drink that cleanses the palate and matches the southwestern dish's vibrant profile.

Fun Twists on Chicken Alfredo

• Vegetarian Protein Swap: Replace chicken with grilled tofu or black beans, maintaining the southwest seasoning for a plant-based protein alternative that keeps the dish's bold flavors intact.
• Gluten-Free Adaptation: Use gluten-free penne pasta and ensure all seasoning ingredients are certified gluten-free, allowing those with wheat sensitivities to enjoy the creamy southwestern experience.
• Low-Carb Option: Substitute pasta with zucchini noodles or cauliflower rice, reducing carbohydrate content while preserving the rich, spicy cream sauce and protein components.
• Dairy-Free Version: Use coconut cream instead of heavy cream and swap cheddar cheese for nutritional yeast or dairy-free cheese alternatives, creating a creamy texture without traditional dairy ingredients.

FAQs

• How spicy is this Southwest Chicken Alfredo?

The seasoning mix includes cayenne pepper, which adds a mild to moderate heat level. You can adjust the spiciness by reducing or increasing the amount of cayenne to suit your personal taste preference.

• Can I make this recipe gluten-free?

Yes, simply substitute the regular penne pasta with a gluten-free pasta variety like those made from rice, corn, or chickpea flour. Ensure all other ingredients are also gluten-free.

• Is this dish suitable for meal prep?

Absolutely! This Southwest Chicken Alfredo can be prepared in advance and stored in the refrigerator for 3-4 days. The flavors actually develop and become more intense when left to sit, making it a great option for make-ahead meals.

• What protein alternatives can I use instead of chicken?

You can easily substitute chicken with shrimp, turkey, or even plant-based protein like tofu or seitan. Just ensure you season and cook the alternative protein similarly to maintain the dish’s signature Southwest flavor profile.

Southwest Chicken Alfredo Recipe

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4.5 from 31 reviews

• Total Time: 35 minutes
• Yield: 8 1x

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Description

Creamy southwest chicken alfredo brings sizzling flavors from Mexican-inspired cuisine to classic Italian pasta. Spicy grilled chicken, zesty peppers, and rich parmesan sauce create a mouthwatering meal that satisfies deep comfort food cravings in every delicious bite.

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Ingredients

Scale 1x2x3x

Protein:

• 1 lb. Chicken Breasts cut into 1-inch strips

Pasta and Cheese:

• 0.5 lb. Penne Pasta
• 1.5 cups Cheddar Cheese, shredded

Additional Ingredients:

• 1 (15 ounces) can Diced Tomatoes
• 1 cup Heavy Cream
• 1 cup Onion, chopped
• 4 Garlic Cloves, minced
• 1 tablespoon Honey
• 1 tablespoon Olive Oil
• 1 tablespoon Butter
• 2 tablespoons Cilantro, chopped

Spices:

• 1.5 teaspoons Chili Powder
• 0.5 teaspoon Cumin
• 0.5 teaspoon Oregano
• 1 teaspoon Paprika
• 0.25 teaspoon Black Pepper
• 0.5 teaspoon Salt
• 0.125 teaspoon Cayenne

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Instructions

1. Craft a zesty southwest seasoning by blending chili powder, cumin, oregano, paprika, black pepper, salt, and cayenne in a small bowl, creating an aromatic spice mix that will elevate the chicken’s flavor profile.
2. Drizzle honey over chicken strips and generously coat with half the prepared seasoning mix, ensuring each piece is thoroughly seasoned for maximum taste.
3. Boil water in a large pot and cook penne pasta until al dente, typically 8-10 minutes. Drain and set aside, preparing for the upcoming creamy sauce.
4. Warm olive oil in a skillet over medium heat (375°F). Sear chicken strips until golden brown and fully cooked, approximately 3-4 minutes per side. Transfer to a separate plate.
5. In the same skillet, melt butter and saute chopped onions until translucent and tender, developing a rich foundational flavor for the sauce.
6. Introduce minced garlic and cook for 60 seconds until fragrant. Add diced tomatoes and remaining seasoning mix, bringing the mixture to a gentle simmer.
7. Gradually pour heavy cream into the skillet, stirring continuously to create a smooth, cohesive sauce. Maintain a low simmer to allow gradual thickening.
8. Return chicken strips to the skillet, sprinkling shredded cheddar cheese over the top. Stir until cheese melts completely, creating a luxurious coating.
9. Incorporate cooked penne pasta into the skillet, thoroughly tossing to ensure each pasta piece is generously covered with the creamy sauce.
10. Remove from heat and let the dish rest for 2-3 minutes, allowing flavors to meld and sauce to slightly thicken.
11. Garnish with freshly chopped cilantro, adding a vibrant, herbaceous finish to the southwest-inspired chicken alfredo.

Notes

• Customize the Southwest seasoning by adjusting cayenne and chili powder levels to control heat intensity.
• Opt for whole wheat or gluten-free pasta to make the dish more diet-friendly and nutritionally diverse.
• Consider using Greek yogurt instead of heavy cream for a lighter, protein-rich alternative that maintains creamy texture.
• Swap chicken with grilled tofu or plant-based chicken for a vegetarian version without compromising flavor complexity.

• Prep Time: 15 minutes
• Cook Time: 20 minutes
• Category: Dinner, Lunch
• Method: Sautéing
• Cuisine: Southwestern American

Nutrition

• Serving Size: 8
• Calories: 670
• Sugar: 3 g
• Sodium: 600 mg
• Fat: 30 g
• Saturated Fat: 16 g
• Unsaturated Fat: 10 g
• Trans Fat: 1 g
• Carbohydrates: 70 g
• Fiber: 4 g
• Protein: 32 g
• Cholesterol: 85 mg